Primary transportation is provided by State and local highways. The Town owns a handicapped accessible van for special programs. Freight delivery is available through rail into the industrial park area. The Connecticut River is also available for transportation.

The highway network consists of approximately 75 miles of roadways, 59.1 miles of which are owned by the Town. The remaining 15.24 miles are State owned. Rt. 66 runs through the southern portion of Town in an east-west direction. Rt. 17 overlaps Rt. 66 for 2.42 miles, and then runs north toward Glastonbury. Rt. 17A consists of Main Street, running from the Arrigoni Bridge to where it meets up with Rt. 17 (at the "Four Corners").

Rt. 9 North, in Middletown, connects to Rt. 91, which leads to Hartford and Massachusetts, or south toward New Haven. Going south on Rt. 9 brings one to the shoreline area, with connections to Rt. 1 and Interstate 95. Rt. 9 North leads to Interstate 84.

The bus service is operated by Middletown Transit District. It runs five days a week, connecting Portland and East Hampton to Middletown. The American Red Cross Dial-a-Ride service for the elderly and handicapped is also available five days a week.

Bradley International Airport is located 27 miles (about 40 minutes) north off Interstate 91 in Windsor Locks. Buses to New York and Boston are available in Middletown.